[HTML][HTML] Mechanisms and consequences of affinity modulation of integrin αVβ3 detected with a novel patch-engineered monovalent ligand
N Pampori, T Hato, DG Stupack, S Aidoudi… - Journal of Biological …, 1999 - ASBMB
Integrin α V β 3 mediates diverse responses in vascular cells, ranging from cell adhesion,
migration, and proliferation to uptake of adenoviruses. However, the extent to which α V β 3
is regulated by changes in receptor conformation (affinity), receptor diffusion/clustering
(avidity), or post-receptor events is unknown. Affinity regulation of the related integrin, α IIb β
3, has been established using a monovalent ligand-mimetic antibody, PAC1 Fab. To
determine the role of affinity modulation of α V β 3, a novel monovalent ligand-mimetic …
migration, and proliferation to uptake of adenoviruses. However, the extent to which α V β 3
is regulated by changes in receptor conformation (affinity), receptor diffusion/clustering
(avidity), or post-receptor events is unknown. Affinity regulation of the related integrin, α IIb β
3, has been established using a monovalent ligand-mimetic antibody, PAC1 Fab. To
determine the role of affinity modulation of α V β 3, a novel monovalent ligand-mimetic …
